Collaboration with Birmingham Women’s NHS Foundation Trust: “AIMS” study, United Kingdom

nhs foundation trust

As a part of the collaboration between the department of Obstetrics & Gynaecology and the Birmingham Women’s NHS Foundation Trust a study on ‘Adherence to Immunomodulators in Multiple Sclerosis: Prevalence and Clinical Impact (AIMS)’ is conducted from 2015 to 2017 in Malawi, Tanzania and Uganda. The study investigates a treatment for a potentially life threatening complication in patients with a genetically inherited disorder known as Marfan Syndrome (MFS). MFS may lead to an expansion of the aorta, which can cause it to tear and rupture. MFS patients are commonly treated with beta blockers, which can slow the expansion of the main blood vessel, however with serious side effects. The current therapy therefore often requires surgical intervention for repairing or replacing the aortic root. The AIMS study tests whether the alternative drug Irbesartan can reduce the aorta expansion. As part of the study, the department of Obstetrics and Gynaecology in Blantyre helps to mobilise and randomise patients. Within the last six months of the year 2014, Malawi has done 322 randomisations and has thereby carried out the most randomizations in comparison to other countries participating in the study such as Tanzania and Uganda.


NHS: “Children’s Hospitals Network: Annual Report 2013/2014″

NHS: Research & Development

AIMS: Newsletter December 2014

National Multiple Sclerosis Society: List of Current Research Projects